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A dosage adjustment is recommended in patients with moderate or severe renal insufficiency and in patients with end-stage renal disease requiring hemodialysis or peritoneal dialysis. President Vladimir Poetin nam alle Russische atleten die betrapt waren in bescherming.
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Noen bivirkninger kan være økt når det brukes i barn. Het kan in bepaalde gevallen beter zijn om voor een alternatieve of veiligere behandeling te kiezen, gezien de stevige bijwerkingen en aanwezige kans op bacteriële-resistentie.